Envision a world without HBV
Innovative therapies
Antios is developing transformative treatments for hepatitis B virus (HBV).
HBV remains a formidable challenge
Even after decades of ongoing effort, the current standard of care is unable to provide a functional cure for HBV infection1
Our lead therapeutic candidate, ATI-2173, is the only active site polymerase inhibitor nucleotide (ASPIN) in development
Discover how our collaborative efforts are helping us achieve our goals
Antios has been exploring combination therapy with other complementary drug classes to shut down viral replication and take the first step toward a potential cure for hepatitis B.2,3
ASPIN MOA
ATI-2173 leverages a novel mechanism of action (MOA) to disrupt polymerase activity and shut down viral replication.1
Antios is currently developing fourth generation capsid assembly modulators (CAMs) for the treatment of HBV1
Our CAMs have the potential to synergize with ATI-2173 and target different stages of the HBV life cycle1
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References: 1. Data on file. Antios Therapeutics, Doylestown, PA. 2. Squires KE, Mayers DL, Bluemling GR, et al. ATI-2173, a novel liver-targeted non-chain-terminating nucleotide for hepatitis B virus cure regimens. Antimicrob Agents Chemother. 2020;64(9):e00836-20. 3. Mayers DL. ATI-2173: a novel active site polymerase inhibitor nucleotide (ASPIN). Presented at: Hep DART; December 5-9, 2021; Los Cabos, Mexico.